2-hydroxymethyl-quinoxaline-1,4-dioxide derivatives, a...

C - Chemistry – Metallurgy – 07 – D

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260/251, 260/248

C07D 241/52 (2006.01) C07D 403/12 (2006.01) C07D 405/12 (2006.01)

Patent

CA 1154017

ABSTRACT The invention relates to new 2-hydroxymethyl-quinoxaline- 1,4-dioxide derivatives of the general formula (I). Image (I) wherein A represents an amino group, or a group of the general formula -NH-COOR1, wherein R stands for a C2-4 alkyl group, or a group of the general formula -NH-CX-NH2, wherein X denotes an oxygen or sulfur atom, or a group of the formula -NH-C(-NH)-NH2, or a group of the general formula -NH-R2, wherein R2 represents-(C1-6 alkyl, a phenyl, a benzyl, a hydroxyl or a hydroxy-(C2-4 alkyl) group, or a group of the general formula -NH-CO-R3, wherein R3 stands for a C1-20 alkyl group or a phenyl group optionally substituted by one, two or three identical or different substituent(s) selected from the group consisting of nitro, hydroxyl, amino, C1-3 alkoxy and halogen; a naphthyl group optionally substituted by a hydroxyl group, a phenyl-(C1-3 alkyl) group, a pyridyl, a piperidyl,.a pyrazinyl, a pyrimidyl, a 1,2,4-triazinyl, a furyl, a nitrofuryl or an .alpha.,.alpha.-diphenyl-.alpha.-hydroxymethyl group. Due to their antimicrobial and weight-gain increasing effects,the new compounds of the general formula (I) can serve as active ingredients, of pharmaceutical or veterinary compositions, particularly fodder concentrates, fodder additives and fodders. The invention relates also to the preparAation of the new compounds of the general formula (I) and the compositions containing same.

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