C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 229/36 (2006.01) C07C 229/34 (2006.01) C07C 233/54 (2006.01) C07C 237/20 (2006.01) C07C 237/22 (2006.01) C07C 255/32 (2006.01) C07C 309/24 (2006.01) C07C 311/35 (2006.01) C07C 317/28 (2006.01) C07C 323/63 (2006.01) C07D 231/36 (2006.01) C07D 237/20 (2006.01)
Patent
CA 2219944
2-Hydroxyphenylalkylamine derivatives having the activity of inhibiting Maillard reaction and represented by general formula (I) and pharmacologically acceptable salts thereof: wherein R1, R2, R3 and R4 may be the same or different and each represents hydrogen, lower alkyl, lower alkoxy, hydroxy, mercapto, halogeno, nitro, amino, acylamino, acyl or hydroxy(lower alkyl); R5 represents hydrogen or lower alkyl; A represents a single bond or lower alkylene or lower alkenylene optionally substituted by hydroxy; Y represents a single bond or lower alkylene; and Z represents carboxy, lower alkoxycarbonyl, aryloxycarbonyl, aralkyloxycarbonyl, carbamoyl, etc.
Dérivés de 2-hydroxyphénylalkylamine à activité inhibitrice de la réaction de Maillard, de formule générale (I) et sels pharmaceutiquement acceptables desdits dérivés. Dans la formule (I), R?1¿, R?2¿, R?3¿ et R?4¿ peuvent être identiques ou différents et chacun représente hydrogène, alkyle inférieur, alcoxy inférieur, hydroxy, mercapto, halogéno, nitro, amino, acylamino, acyle ou hydroxy(alkyle inférieur); R?5¿ représente hydrogène ou alkyle inférieur; A représente une liaison simple ou alkylène inférieur ou alcénylène inférieur éventuellement substitué par hydroxy; Y représente une liaison simple ou alkylène inférieur; et Z représente carboxy, alcoxyalkyle inférieur, aryloxycarbonyle, aralkyloxycarbonyle, carbamyle, etc.
Harada Hiromu
Iyobe Akira
Kamata Koji
Katsuno Kenji
Kobayashi Miho
Kirby Eades Gale Baker
Kissei Pharmaceutical Co. Ltd.
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