2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and...

Details 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and... 2-(ih-thieno [3,2-c] pyrazol-3yl)-ih-indole derivatives and...

C - Chemistry, Metallurgy

07

D

C07D 495/04 (2006.01) A61K 31/4184 (2006.01) A61P 11/00 (2006.01) A61P 29/00 (2006.01) A61P 37/00 (2006.01)

Patent

CA 2634061

Disclosed are compounds of formula (I): (F) wherein R1, R2, X and Ar are defined herein. The compounds of the invention inhibit Itk kinase and are therefore useful for treating diseases and pathological conditions involving inflammation, immunological disorders and allergic disorders. Also disclosed are processes for preparing these compounds and to pharmaceutical compositions comprising these compounds.

L'invention concerne des composés de formule (I) : (F) dans laquelle R1, R2, X et Ar ont les définitions indiquées dans la présente. Les composés de l'invention inhibent la kinase Itk et sont donc utiles pour traiter des maladies et des pathologies impliquant une inflammation, des troubles immunologiques et des troubles allergiques. L'invention concerne en outre des procédés de préparation de ces composés, ainsi que des compositions pharmaceutiques comprenant ces composés.

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