C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 403/12 (2006.01) A61K 31/495 (2006.01)
Patent
CA 2087606
A compound selected from the group consisting of those having the formula: (see formula I) and pharmaceutically acceptable acid addition salts thereof, wherein R1 and R4 are independently selected from the group consisting of H and alkyl radicals having 1 to 4 carbon atoms; the R2s are each H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo; the R3s are each H or alkyl radicals having 1 to 4 carbon atoms or are, together, oxo, provided that the R2s or the R3s are alkyl radicals; the 2-imidazolin-2- ylamino group may be in any of the 5-, 6, 7- or 8- positions of the quinoxaline nucleus; and R5, R6 and R7 each is located in one of the remaining 5-, 6-, 7- or 8- positions of the quinoxaline nucleus and is independently selected from the group consisting of Cl, Br, H and alkyl radicals having 1 to 3 carbon atoms. Such compounds, when administered to a mammal, provide desired therapeutic effects, such as alteration in the rate of fluid transport in the gastrointestinal tract, reduction in intraocular pressure, and increase in renal fluid flow.
Allergan Inc.
Gowling Lafleur Henderson Llp
LandOfFree
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