2-imidazoline derivatives, process for the preparation...

Details 2-imidazoline derivatives, process for the preparation... 2-imidazoline derivatives, process for the preparation...

C - Chemistry, Metallurgy

07

D

260/305.1, 260/3

C07D 233/50 (2006.01) C07D 403/00 (2006.01)

Patent

CA 1138451

ABSTRACT New 2-imidazoline derivatives are provided of the formula: Image (1) wherein R1 is aryl which may have 1 to 5 substi- tuents(s) selected from the groups consisting of halogen, lower alkyl, lower alkoxy, lower alkanesulfo- namido, mono(alkyl), carbomoyl, hydroxy, nitro, amino, cyano, sulfamoyl, N,N-di(lower)alkylsulfamoyl, and di(lower)alkylamino which may form a 3 to 7-membered ring with or with- out an oxygen or nitrogen atom; R2 and R3 are each hydrogen, halogen, lower alkyl, lower alkoxy, lower alkanesulfonamido, mono(or di or tri)?halo(lower)alkyl, carbamoyl, hydroxy, nitro, amino, cyano, sulfamoyl, N,N-di(lower)alkyl- sulfamoyl, or di(lower)alkylamino which may form a 3 to 7-membered ring with or without an oxygen or another nitrogen atom; A is 0-, -5- or -CH2-; and n is an integral number of 0 or 1, and pharmaceutically acceptable salts thereof; the derivatives have anti- hypertensive, anti-inflammatory, analgenic and anti-ulcer activities, and can be used for therapeutical treatment of hypertensive, inflammatory and gastrointestinal disorder and for relief from pain of various origins in human beings.

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