2-iodo-3-keto-delta4-steroids, process for producing them...

Details 2-iodo-3-keto-delta4-steroids, process for producing them... 2-iodo-3-keto-delta4-steroids, process for producing them...

C - Chemistry, Metallurgy

07

J

C07J 1/00 (2006.01)

Patent

CA 2082503

ABSTRACT The new intermediate products of general formula I Image (I), in which R1 stands for a hydrogen atom or a straight-chain or branched alkyl group with 1 to 4 carbon atoms, R2 stands for a hydrogen atom or a methyl group, R3 stands for a hydrogen atom as well as R4 stands for an acyloxy group with l to 4 carbon atoms in the acyl radical or else R3 and R4 together stand for a keto-oxygen atom, are suitable in an excellent way for introducing a .DELTA.1 double bond in the steroid skeleton with the simultaneous presence of a .DELTA.4 double bond as well as saturated carbonyl groups by cleavage of hydrogen iodide with a base in an amidic solvent at elevated temperature. If R2 stands for a hydrogen atom, the A-ring is aromatized after the hydrogen iodide cleavage. For the production of new intermediate products, special iodization processes, which partially also allow a stereoselective control of the iodization, are used.

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