¬2-(l-piperidinyl)-phenyl|-phenyl methanone

Details ¬2-(l-piperidinyl)-phenyl|-phenyl methanone ¬2-(l-piperidinyl)-phenyl|-phenyl methanone

C - Chemistry, Metallurgy

07

D

260/292

C07D 211/06 (2006.01) C07D 211/14 (2006.01) C07D 211/46 (2006.01) C07D 295/10 (2006.01) C07D 295/135 (2006.01)

Patent

CA 1187501

-20- ABSTRACT The present invention relates to new benzoyl-phenyl- piperidine derivatives selected from the group consisting of: 1) 2-piperidinobenzophenones of the general formula: Image (I) in which: - R1, R2 and R3, which are identical or different, each represent an atom of hydrogen, a hydroxy group, CF3, a halogen, a lower alkyl group or a lower alkoxy group; - R4 represents an atom of hydrogen, a halogen, an NO2 group, an NR'R" group [where R' and R", which are identical or different, represent an atom of hydrogen, a lower alkyl group or a CO2R group (where R represents a lower alkyl group or a benzyl group)]; - R5 and R6, which are identical or different, each represent an atom of hydrogen, a C1-C4-alkyl group, an OH group, a phenyl group or a benzyl group; and ii) acid addition salts thereof. The invention also relates to the method for preparing these new derivatives and to their use in therapeutics, particularly as immunostimulant and immunoadjuvant agents.

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