2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]oc...

Details 2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]oc... 2-methoxymethyl-3-(3,4-dichlorophenyl)-8-azabicyclo[3.2.1]oc...

C - Chemistry, Metallurgy

07

D

C07D 451/04 (2006.01) A61K 31/46 (2006.01)

Patent

CA 2534295

This invention relates to novel (1R,2R,3S,5S)-2-methoxymethyl-3- (3,4dichlorophenyl)-8-azabicyclo[3.2. 1 ]octane tartrate salts, such as L- tartrate monohydrates and anhydrates. The salts are useful as monoamine neurotransmitter re-uptake inhibitors. In other aspects the invention relates to the use of these salts in a method for therapy and to pharmaceutical compositions comprising the salts of the invention.

L'invention concerne des sels de (1R,2R,3S,5S)-2-méthoxyméthyl-3-(3,4dichlorophényl)-8-azabicyclo[3.2. 1 ] octane tartrate, tels que des monohydrates et des anhydrates de L-tartrate. Les sels sont utiles comme inhibiteurs du recaptage des neurotransmetteurs monoamine. D'autres modes de réalisation de l'invention concernent l'utilisation de ces sels dans une méthode de thérapie et des compositions pharmaceutiques renfermant les sels selon l'invention.

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