2-methoxyphenylpiperazine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 471/04 (2006.01) A61K 31/425 (2006.01) A61K 31/435 (2006.01) A61K 31/505 (2006.01) C07D 487/04 (2006.01) C07D 513/04 (2006.01)

Patent

CA 2269814

The invention relates to novel fused heterocyclic compounds with ring junction nitrogen atom of formula (I), wherein Q stands for 2-indolizinyl, 2- imidazo[1,2-a]pyridinyl, 2-imidazo[1,2-a]pyrimidinyl, 6-(2,3- dihydroimidazo[2,1-b]thiazol)-yl or 6-imidazo[2,1-b]thiazolyl group; and n is an integer from 2 to 4, as well as their therapeutically useful salts thereof. The invention further relates to pharmaceutical compositions containing these compounds as well as a process for the preparation of the above compounds and compositions. The novel compounds of formula (I) exhibit mainly antipsychotic effects so the invention relates also to a method of treatment of schizophrenia, organic mental disorders, affective disorders, anxiety and personality disorders.

L'invention concerne de nouveaux composés hétérocycliques condensés avec un atome d'azote à la jonction du cycle, de formule (I), dans laquelle Q représente les groupes 2-indolizinyle, 2-imidazo[1,2-a]pyridinyle, 2-imidazo[1,2-a]pyrimidinyle, 6-(2,3-dihydroimidazo[2,1-b]thiazol)-yle ou 6-imidazo[2,1-b]thiazolyle, et n est un entier compris entre 2 et 4, ainsi que leurs sels utiles sur le plan thérapeutique. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi qu'un procédé permettant de préparer lesdits composés et compositions. Les nouveaux composés de formule (I) présentent une activité principalement antipsychotique, si bien que l'invention concerne également une méthode permettant de traiter la schizophrénie, les troubles mentaux organiques, les troubles affectifs, l'angoisse et les troubles de la personnalité.

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