2-methyl-5-(2-hydroxystyral)-1,3,4-thiadiazole

Details 2-methyl-5-(2-hydroxystyral)-1,3,4-thiadiazole 2-methyl-5-(2-hydroxystyral)-1,3,4-thiadiazole

C - Chemistry, Metallurgy

07

D

260/308.3

C07D 285/12 (2006.01) C07F 9/6539 (2006.01)

Patent

CA 1128049

O.Z. 0050/033156 Abstract of the disclosure: 2-Methyl-5-(2-hydroxystyryl)- 1,3,4-thiadiazole of the formula Image (I) and processes for its preparation by condensing salicylalde- hyde with 2,5-dimethyl-1,3,4-thiadiazole or 2-methyl-5-(tri- phenylphosphine-methylene)-1,3,4-thiadiazole. 2-Methyl- 5-(2-hydroxystyryl)-1,3,4-thiadiazole is a valuable inter- mediate for the preparation of pharmacologically active compounds; for example the alkylamino-hydroxypropyl ethers can because of their .beta.-sympatholytic action, be used as drugs for the treatment of coronary diseases of the heart, cardiac arrhythmias and hypertonia.

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