2-methyl-dihydropyridine compound, processes for preparation...

Details 2-methyl-dihydropyridine compound, processes for preparation... 2-methyl-dihydropyridine compound, processes for preparation...

C - Chemistry, Metallurgy

07

D

260/294.2, 260/2

C07D 211/90 (2006.01) C07C 205/56 (2006.01) C07D 213/55 (2006.01) C07D 333/24 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 1117117

ABSTRACT OF THE DISCLOSURE New 2-methyl-dihydropyridines are provided of the formula: Image (I) wherein R1 is phenyl,3-nitrophenyl, 2-chlorophenyl, 2-trifluoro- methylphenyl, 2-methoxyphenyl, 2-allyloxyphenyl, 2,4-dichloro- phenyl, 3,4-dichlorophenyl, 3,4-dimethoxyphenyl, 2-tolyl, 4-pyridyl or 2-thienyl, R2 is propyl, isopropyl, 2-chloroethyl, 2-hydroxyethyl, 2-ethoxyethyl, 2-phenoxyethyl, 2-benzyloxy- ethyl or 2-(N-benzyl-N-methyl-amino)ethyl. R3 is lower alkyl, and R4 is di(lower)alkoxymethyl, formyl, hydroxymethyl or cyano, provided that, when R1 is 3-nitrophenyl, then R2 is 2-hydroxy- ethyl and R4 is cyano or formyl, or R2 is propyl or isopropyl, and pharmaceutically acceptable salts thereof; the new derivative have vasodilating and anti-hypertensive activities and may be employed in the therapeutical treatment of cardio- vascular disorder and hypertension.

336130

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