2-methylene-19-nor-vitamin d2 compounds

Details 2-methylene-19-nor-vitamin d2 compounds 2-methylene-19-nor-vitamin d2 compounds

A - Human Necessities

61

K

A61K 38/00 (2006.01) A61K 31/59 (2006.01)

Patent

CA 2535185

2-Methylene-19-nor-24(S) and 24(R) derivatives of 1a,25-dihydroxyvitamin D2 are disclosed. These compounds are characterized by minimal bone calcium mobilization activity and relatively high intestinal calcium transport activity. This results in novel therapeutic agents for the treatment of diseases such as renal osteodystrophy, autoimmune diseases, and osteoporosis. These compounds also exhibit pronounced activity in arresting the proliferation of undifferentiated cells and inducing their differentiation to the monocyte thus evidencing use as anticancer agents and for use treating skin diseases such as psoriasis.

Cette invention se rapporte à des dérivés 2-Méthylène-19-nor-24(S) et 24(R) de 1.alpha., 25-dihydroxyvitamine D¿2?. Ces composés se caractérisent par une activité minimale de mobilisation du calcium osseux et par une activité relativement forte de transport du calcium intestinal. On obtient ainsi de nouveaux agents thérapeutiques pouvant servir au traitement des maladies telles que l'ostéodystrophie rénale, les maladies auto-immunes et l'ostéoporose. Ces composés présentent également une action prononcée d'interruption de la prolifération des cellules non différenciées et d'induction de leur différentiation dans le monocyte, ce qui permet de les utiliser comme agents anticancéreux et pour traiter les maladies de la peau telles que le psoriasis.

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