C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 233/05 (2006.01) A61K 31/165 (2006.01)
Patent
CA 2584502
The present invention relates to inhibitors of 11-~ hydroxyl steroid dehydrogenase type 1, antagonists of the mineralocorticoid receptor (MR), and pharmaceutical compositions thereof. The compounds of the invention can be useful in the treatment of various diseases associated with expression or activity of 11-~ hydroxyl steroid dehydrogenase type 1 and/or diseases associated with aldosterone excess.
La présente invention concerne des inhibiteurs de la 11-ß hydroxyl stéroïde déhydrogenase type 1, des antagonistes du récepteur minéralocorticoïde et des compositions pharmaceutiques les renfermant. Les composés de l'invention peuvent convenir pour le traitement de diverses pathologies associées à l'expression ou à l'activité de la 11-ß hydroxyl stéroïde déhydrogenase type 1 et ou des maladies associées à un excès d'aldostérone.
Agrios Konstantinos
Metcalf Brian W.
Xu Meizhong
Yao Wenqing
Zhang Colin
Incyte Corporation
Smart & Biggar
LandOfFree
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