2-methylpropionic acid derivatives and medicinal...

Details 2-methylpropionic acid derivatives and medicinal... 2-methylpropionic acid derivatives and medicinal...

C - Chemistry, Metallurgy

07

C

C07C 217/60 (2006.01) A61K 31/195 (2006.01) A61K 31/216 (2006.01) C07C 229/18 (2006.01)

Patent

CA 2328348

The present invention provides novel 2-methylpropionic acid derivatives represented by the general formula: (see formula I) (wherein R1 represents a hydrogen atom, a lower alkyl group or an aralkyl group; R2 represents a hydrogen atom, a lower alkyl group or a halogen atom; A represents an oxygen atom or an imino group; the carbon atom marked with (R) represents a carbon atom in R configuration; and the carbon atom marked with (S) represents a carbon atom in S configuration) and pharmaceutically acceptable salts thereof, which have excellent .beta.3-adrenoceptor stimulating effects and are useful as agents for the prevention or treatment of obesity, hyperglycemia, the diseases caused by intestinal hypermotility, pollakiuria, urinary incontinence, depression, or the diseases caused by biliary calculi or hypermotility of biliary tract.

L'invention a pour objet de nouveaux dérivés de l'acide 2-méthylpropionique correspondant à la formule générale suivante (I) et leurs sels pharmaceutiquement acceptables possédant un excellent effet stimulant sur les récepteurs d'adrénaline beta 3 et servant à la prévention ou à la thérapie de l'obésité, de l'hypoglycémie, des maladies causées par le mouvement intestinal accéléré, des mictions fréquentes, de l'incontinence urinaire, de la dépression, de la lithiase biliaire ou des maladies provoquées par le mouvement biliaire accéléré. Dans la formule générale (I) R<1> représente hydrogène, alkyle inférieur ou aralalkyle; R<2> représente hydrogène, alkyle inférieur ou halogéno; A représente hydrogène ou imino; l'atome de carbone auquel est attaché (R) est unique dans la configuration (R); et l'atome de carbone auquel est attaché (S) est unique dans la configuration (S).

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