2-morpholin-4-yl-pyrimidines as pi3k inhibitors

Details 2-morpholin-4-yl-pyrimidines as pi3k inhibitors 2-morpholin-4-yl-pyrimidines as pi3k inhibitors

C - Chemistry, Metallurgy

07

D

C07D 401/14 (2006.01) A61K 31/5377 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2683622

The invention provides compounds which are pyrimidines of formula (I) wherein R1 is a group -NR-(CHR)m-X; R2 is a substituted indolyl group; R is H or C1-C6 alkyl; m is 1, 2, 3 or 4; and X is a pyridyl ring; and the pharmaceutically acceptable salts thereof. These compounds are inhibitors of PI3K and may thus be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine function disorders and neurological disorders.

L'invention concerne des composés qui sont des pyrimidines de formule (I) dans laquelle R1 représente un groupe -NR-(CHR)m-X; R2 représente un groupe indolyle substitué; R représente H ou alkyle en C1-C6; m vaut 1, 2, 3 ou 4 et X représente un noyau pyridyle. L'invention concerne également les sels pharmaceutiquement acceptables de ces composés. Ces composés sont des inhibiteurs de PI3K et peuvent donc être utilisés pour traiter des maladies et des troubles provenant d'une prolifération, d'une fonction ou d'un comportement cellulaire anormal associé à la kinase PI3, tels que le cancer, les maladies immunes, les maladies cardio-vasculaires, les infections virales, les inflammations, les troubles de la fonction métabolique/endocrine et les troubles neurologiques.

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