2'-n-acyl and alkyl-6'-n-alkyl and 6',6'-di-n-alkyl...

Details 2'-n-acyl and alkyl-6'-n-alkyl and 6',6'-di-n-alkyl... 2'-n-acyl and alkyl-6'-n-alkyl and 6',6'-di-n-alkyl...

C - Chemistry, Metallurgy

07

H

260/300, 260/360

C07H 15/22 (2006.01) C07H 15/224 (2006.01)

Patent

CA 1126743

Abstract of the Disclosure Novel fortimicin derivatives represented by the formula Image wherein: R is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-dilower- alkylaminoloweralkyl, aminohydroxyloweralkyl, N-loweralkyl- aminohydroxyloweralkyl or N,N-diloweralkylaminohydroxyloweralkyl; R1 is loweralkyl, R2 is hydrogen or lower alkyl; and R3 is acyl, aminoacyl, N-monoloweralkylaminoacyl, N,N-diloweralkyl- aminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminoloweralkyl, hydroxylower- alkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylamino- loweralkyl, aminohydroxyloweralkyl, N-loweralkylaminohydroxy- loweralkyl, N,N-diloweralkylaminohydroxyloweralkyl or hydrogen and the pharmaceutically acceptable salts thereof: pharma- ceutical compositions containing the compounds; and methods of making and using the compounds. The compounds are useful as antibiotics.

317382

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