C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
260/300, 260/360
C07H 15/22 (2006.01) C07H 15/224 (2006.01)
Patent
CA 1128534
Abstract 2'-N-Acyl and alkyl fortimicin B and fortimicin n derivatives, 4,2'-N, N'-diacyl and dialkyl derivatives, 4- N-acyl-2'-N-alkyl and 4-N-alkyl-2'-N-acyl fortimicin B derivatives represented by the formula Image wherein: R is acyl, aminoaevl, N-monoloweralkylaminoacyl, N,N-diloweralkylaminoacyl, hydroxy-substituted aminoacyl, hydroxyacyl, an amino acid residue, loweralkyl, aminolower- alkyl, hydroxyloweralkyl, N-loweralkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxyloweralky, N-loweralkylaminohydroxyloweralkyl or N,N-dilowera1kylnmino- hydroxyloweralkyl; and R1 is acyl, aminoaeyl, N-monolower- alkylaminoacyl, N,N-diloweralkylaminoaeyl, hydroxy-substituted aminoacyl, an amino acid residue, hydroxyacyl, loweralkyl, aminoloweralkyl, hydroxyloweralkyl, N-loweralkylaminolower- alkyl, N,N-diloweralkylaminoloweralkyl, aminohydroxylower- alkyl, N-loweralkylaminohydroxyloweralkyl, N,N-diloweralkyl- aminohydroxyloweralkyl or hydroqen and the pharmaccutically acceptable salts thereof; pharmaceutical compositions containing the compounds; and methods of makinq and using the compounds. The fortimicin derivatives of this invention are antiblotics.
314112
Collum Paulette
Martin Jerry R.
Tadanier John S.
Abbott Laboratories
Macrae & Co.
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