C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/208, 260/262
C07D 417/04 (2006.01) A61K 31/395 (2006.01) C07C 45/46 (2006.01) C07C 45/70 (2006.01) C07C 45/71 (2006.01) C07C 49/175 (2006.01) C07C 49/227 (2006.01) C07C 49/255 (2006.01) C07C 57/58 (2006.01) C07C 57/60 (2006.01) C07C 277/08 (2006.01) C07C 279/28 (2006.01) C07D 213/75 (2006.01) C07D 233/54 (2006.01) C07D 277/24 (2006.01) C07D 277/40 (2006.01) C07D 277/48 (2006.01) C07D 277/56 (2006.01) C07D 307/52 (2006.01) C07D 333/20 (2006.01) C07D 417/14 (2006.01) C07D 521/00 (2006.01)
Patent
CA 1262352
2-(N-SUBSTITUTEDGUANIDINO)-4-HETERO- ARYLTHIAZOLE ANTIULCER AGENTS Abstract 2,4-Disubstituted thiazole compounds of the formula Image ---(I) or a pharmaceutically acceptable acid addition salt thereof wherein X is NH and Y is CH or N, or X is S and Y is CH; R1 is certain straight or hranched chain alkyl groups, (R3)2C6H3, or (R3)2Ar(CH2)n where n is an integer from 1 to 4, R3 is H or certain substituent groups and Ar is phenylene, naphthalene or the residue of certain heteroaromatic groups; R2 is H or (C1-C4)alkyl; or R1 and R2 taken together with the nitrogen atom to which they are attached form certain heterocyclic groups; and R4 is H, (C1-C5)alkyl, NH2 or CH2OH; a method for their use in treatment of gastric ulcers in mammals and parmaceutical compositions containing said compounds.
480150
Limited Pfizer
Smart & Biggar
LandOfFree
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