2'-o-aminoethyloxyethyl-modified oligonucleotides

Details 2'-o-aminoethyloxyethyl-modified oligonucleotides 2'-o-aminoethyloxyethyl-modified oligonucleotides

C - Chemistry, Metallurgy

07

H

C07H 21/04 (2006.01) C07H 21/00 (2006.01) C12N 15/11 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2339178

2'-O-Modified ribosyl nucleosides and modified oligomeric compounds containing such nucleosidic monomers are disclosed. Oligomeric compounds are disclosed that have increased binding affinity as shown by molecular modelling experiments. The 2'-O-modified nucleosides of the invention include ring structures that position the sugar moiety of the nucleosides preferentially in 3' endo geometries.

L'invention concerne des ribosyl nucléosides 2'-O- modifiés et de composés oligomères modifiées contenant de tels monomères nucléosidiques. L'invention concerne également de composés oligomères qui présentent une affinité de liaison accrue ainsi que le démontrent les expériences de modélisation moléculaire. Ces nucléosides 2'-O-modifiés comprennent des structures cycliques dans lesquelles la fraction glucose des nucléosides est positionnée de préférence en 3'endo.

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