2-o sulfatase compositions and related methods

Details 2-o sulfatase compositions and related methods 2-o sulfatase compositions and related methods

C - Chemistry, Metallurgy

12

N

C12N 9/16 (2006.01) C12N 15/00 (2006.01)

Patent

CA 2512673

The invention relates to 2-O sulfatase and uses thereof. In particular, the invention relates to recombinantly produced 2-O sulfatase, functional variants and nucleic acid molecules that encode these molecules. The invention also provides methods of using 2-O sulfatase for a variety of purposes, including degrading and analyzing glycosaminoglycans (GAGS) present in a sample. For instance, 2-O sulfatase may be used for determining the purity, identity, composition and sequence of glycosaminoglycans present in a sample. The invention also relates to methods of inhibiting angiogenesis and cellular proliferation as well as methods for treating cancer, neurodegenerative disease, atherosclerosis and microbial infection using 2-O sulfatase and/or GAG fragments produced by degradation with 2-O sulfatase.

L'invention concerne la 2-O sulfatase et ses utilisations. Plus particulièrement, l'invention concerne la 2-O sulfatase produite par recombinaison, des variants fonctionnels et des molécules d'acide nucléique codant pour ces molécules. L'invention concerne également des méthodes d'utilisation de la 2-O sulfatase à des fins diverses, y compris la dégradation et l'analyse de glycosaminoglycanes (GAG) présents dans un échantillon. Par exemple, la 2-O sulfatase peut être utilisée pour déterminer la pureté, l'identité, la composition et la séquence des glycosaminoglycanes présents dans un échantillon. L'invention se rapporte en outre à des méthodes destinées à inhiber l'angiogenèse et la prolifération cellulaire, ainsi qu'à des méthodes de traitement du cancer, de la maladie neurodégénérative, de l'athérosclérose et de l'infection microbienne au moyen de la 2-O sulfatase et/ou de fragments de GAG produits par dégradation avec la 2-O sulfatase.

Affiliated with

Also associated with

Rating

2-o sulfatase compositions and related methods does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 2-o sulfatase compositions and related methods, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-o sulfatase compositions and related methods will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFCA-PAI-O-1549489