2-oxo-1-oxa-8-azaspiro /4,5/decane derivatives,...

C - Chemistry – Metallurgy – 07 – D

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C07D 491/113 (2006.01) A61K 31/54 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2023014

23305-1163 A B S T R A C T The invention relates to novel 2-oxo-1-oxa-8-azaspiro- [4,5]decane derivatives of the formula (I), Image (I) wherein X means oxygen or an Image group, wherein R stands for hydrogen, a C1-12alkyl, C3-6cycloalkyl, carbocyclic C6-10aryl or carbocyclic C6-10aryl- C1-4alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more, same or different halogen(s), one or more C1-4alkyl or C1-4alkoxy group(s); R1 and R2 together represent a methylene group or, when X stands for an Image group, wherein R is as defined above, one of R1 and R2 may represent a hydroxyl group, where- as the other is a methyl group; Z stands for hydrogen, halogen, trihalomethyl or a C2-4alkanoyl group; and n is 2 or 3, 23305-1163 as well as their acid addition and quaternary ammonium salts. The invention further relates to pharmaceutical compo- sitions containing these compounds and a process for their preparation. The compounds of the formula (I) possess psychotropic and antiallergic properties and a low toxicity. Thus, they are useful for the treatment of psychiatric and allergic diseases.

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