C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/211, 260/278
C07D 491/113 (2006.01) A61K 31/445 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 498/10 (2006.01)
Patent
CA 2023027
NOVEL 2-OXO-1-OXA-3-AZASPIRO[4,5]DECANE DERIVATIVE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR PREPARING SAME Abstract The invention relates to novel 2-oxo-1-oxa-8-aza- spiro[4,5]decane derivatives of the formula (I), Image (I) wherein X means oxygen or an ?NR group, wherein R stands for hydrogen; a C1-12alkyl; C3-6cycloalkyl; carbocyclic C6-10aryl or carbocyclic C6-10aryl- -C1-4alkyl group, the two latter ones being optionally substituted on their aromatic part by one or more, same or different halogen(s), one or more C1-4alkyl, C1-4alkoxy or trihalomethyl group(s); or a tosyl group; R1 and R2 together represent a methylene group or, when X stands for an ?NR group wherein R is as defined above, one of R1 and R2 may represent a hydroxyl goup and the other one is a methyl group; and R3 means hydrogen, benzyl, (C1-4alkoxy)carbonyl, phenoxy- carbonyl, benzyloxycarbonyl, formyl, piperidin-l-yl- carbonyl, morpholin-4-ylcarbonyl, 4-methylpiperazin- -l-ylcarbonyl, 4-(2-hydroxyethyl)piperazin-1-ylcar- bonyl, 2-chloro-3-nicotinoylcarbamoyl or C1-6alkyl- carbamoyl group, as well as their acid addition and quaternary ammonium salts. The invention further relates to pharmaceutical composi- tions containing these compounds and a process for their pre- paration. The compounds of formula (I) possess anticonvulsive, antiallergic and lipid level lowering effects. Thus, they are useful for the treatment of epileptic and allergic diseases and increased lipid levels.
Auth Ferenc
Gaal Laszlo
Groo Dora
Hegedus Bela
Kiss Bela
Fetherstonhaugh & Co.
Richter Gedeon Vegyeszeti Gyar Rt.
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