2-oxo-1-[[(substituted sulfonyl)amino]- carbonyl]azetidines

Details 2-oxo-1-[[(substituted sulfonyl)amino]- carbonyl]azetidines 2-oxo-1-[[(substituted sulfonyl)amino]- carbonyl]azetidines

C - Chemistry, Metallurgy

07

D

260/300, 260/336

C07D 205/08 (2006.01) C07D 205/085 (2006.01) C07D 403/12 (2006.01) C07D 417/12 (2006.01) C07D 521/00 (2006.01)

Patent

CA 1246572

ABSTRACT Antibacterial activity is exhibited by .beta.-lactams having a Image substituent in the 1-position and an acylamino substituent in the 3-position wherein Z is oxygen or sulfur and R is alkyl, alkenyl, alkynyl, substituted alkyl, phenyl, substituted phenyl, a 5,6 or 7-membered heterocycle (Rc), phenylalkyl, (substituted-phenyl)alkyl, Rc-alkyl or -NRaRb wherein Ra and Rb are the same or different and each is hydrogen, alkyl, substituted alkyl, phenyl, substituted phenyl, phenylalkyl, (substituted phenyl)alkyl or one of Ra and Rb is hydrogen, alkyl, phenyl, substituted phenyl, phenylalkyl or (substituted phenyl)alkyl and the other is amino (-NH2), alkanoylamino, arylcarbonylamino, alkoxy- carbonylamino, alkylsulfonylamino, alkylamino, dialkylamino, phenylamino, (substituted phenyl)- amino, hydroxy, cyano(-C?N), alkoxy, phenyloxy, (substituted phenyl)oxy, phenylalkoxy, (substituted phenyl)alkoxy, Rc as defined above, Rc-alkyl, Rc-alkoxy, alkylsulfonyl, alkylmethyleneamino, (alkyl-CH=N-), phenylmethyleneamino or (substituted phenyl)methyleneamino.

398357

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