2-oxo-3,8-diazaspiro /4,5/decane derivatives, pharmaceutical...

Details 2-oxo-3,8-diazaspiro /4,5/decane derivatives, pharmaceutical... 2-oxo-3,8-diazaspiro /4,5/decane derivatives, pharmaceutical...

C - Chemistry, Metallurgy

07

D

167/231, 260/278

C07D 491/113 (2006.01) A61K 31/445 (2006.01) C07D 491/10 (2006.01) C07D 498/10 (2006.01)

Patent

CA 2023018

The invention relates to novel, therapeutically active 2-oxo-3,8-diazaspiro[4,5]decane derivatives of the formula (I), Image (I) wherein R means hydrogen, a C1-12alkyl, C3-6cycloalkyl, carbocyc- lic C6-10aryl or carbocyclic C6-10aryl-C1-4alkyl group, the two latter ones optionally being substituted on their aromatic part by one or more, same or different halogen(s) or one or more C1-4alkyl or C1-4alkoxy group(s); one of R1 and R2 stands for a hydroxyl group whereas the other means a methyl group; R3 and R4, which are the same or different, represent hydro- gen, one or more halogen(s), C1-4alkyl, C1-4alkoxy, trihalomethyl group or a hydroxyl group optionally es- terified by a C1-4alkanoic acid; and n is 1 or 2, their isomers, solvates, hydrates, acid addition and quater- nary ammonium salts. The invention further relates to pharmaceutical compo- sitions containing these compounds and a proces for their preparation. The compounds of the formula (I) exert antihypoxic effects in the central nervous system and therefore, they are useful for the prevention and treatment of disturbances of the cognitive functions as well as mania, agitation, psy- chomotor disquiet, senile and multi-infarctual dementia and Alzheimer's disease.

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