C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 233/32 (2006.01) A61K 31/4166 (2006.01) A61K 31/4184 (2006.01) A61K 31/422 (2006.01) A61K 31/427 (2006.01) A61K 31/4439 (2006.01) A61K 31/4709 (2006.01) A61K 31/495 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 35/00 (2006.01) C07D 235/02 (2006.01) C07D 401/06 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 405/02 (2006.01) C07D 409/02 (2006.01) C07D 413/02 (2006.01) C07D 417/02 (2006.01) C07D 473/00 (2006.01) C07D 487/10 (2006.01) C07D 491/107 (2006.01) C07D 495/10 (2006.01)
Patent
CA 2340138
Disclosed are novel compounds of the formula: (see formula I) (wherein R1 is aryl, heteroaryl, arylalkyl, heteroarylalkyl, arylaryl or the like; R2 and R3 are each H or alkyl or together form a spiro ring; R4 is H or alkyl), and pharmaceutically acceptable salts and solvates thereof, that are useful, for example, as matrix metalloproteinase inhibitors. Also disclosed are pharmaceutical compositions comprising such compounds and methods of treatment for diseases such as osteoarthritis, rheumatoid arthritis, cancer, osteoporosis, tissue ulceration, restinosis, periodontal disease, inflammation, epidermolysis bullosa, scleritis, stroke, Alzheimer's disease, and the like, characterized by inappropriate matrix metalloproteinase activity. Processes for the synthesis of compounds of formula (I) are also disclosed.
Laird Ellen Ruth
Robinson Ralph Pelton Jr.
Pfizer Products Inc.
Smart & Biggar
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