2-oxoquinoline compounds and pharmaceutical uses thereof

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 215/48 (2006.01) A61K 31/47 (2006.01) A61K 31/4709 (2006.01) A61K 31/5355 (2006.01) A61K 31/706 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) A61P 37/08 (2006.01) C07D 215/227 (2006.01) C07D 215/54 (2006.01) C07D 401/12 (2006.01) C07D 405/12 (2006.01) C07H 15/203 (2006.01)

Patent

CA 2358879

2-Oxoquinoline compounds represented by general formula [I] or medicinally acceptable salts thereof; and medicinal uses of both (wherein each symbol is as defined in the description). The compounds [I] and the salts act selectively on cannabinoid receptors, particularly peripheral ones, little have adverse effects on the central nervous system, and exhibit excellent immunosuppressive, anti-inflammatory and antiallergic activities, thus being useful as regulators against cannabinoid receptors (particularly peripheral cannabinoid receptors), and immunosuppressive, anti-inflammatory and antiallergic agents.

Composés de 2-oxoquinoline représentés par la formule générale (I) ou leurs sels acceptables en médecine et utilisations médicinales de ceux-ci (formule dans laquelle chaque symbole est tel que défini dans la description). Les composés (I) ainsi que les sels agissent sélectivement sur les récepteurs cannabinoïdes, notamment les récepteurs périphériques, ils présentent peu d'effets secondaires indésirables sur le système nerveux central et ils présentent d'excellentes activités immunodépressives, anti-inflammatoires et anti-allergiques, et ils sont par conséquent utiles en tant que régulateurs contre les récepteurs cannabinoïdes (notamment les récepteurs cannabinoïdes périphériques), et agents immunodépresseurs, anti-inflammatoires et anti-allergiques.

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