2-phenoxy pyrimidinone analogues

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 473/30 (2006.01) A61K 31/519 (2006.01) A61K 31/522 (2006.01) C07D 471/04 (2006.01) C07D 495/04 (2006.01) C07D 513/04 (2006.01) G01N 33/566 (2006.01)

Patent

CA 2660957

2-Phenoxy pyrimidinone analogues are provided, of the Formula: wherein variables are as described herein. Such compounds are ligands that may be used to modulate specific receptor activity in vivo or in vitro, and are particularly useful in the treatment of conditions associated with pathological receptor activation in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for using such compounds to treat such disorders are provided, as are methods for using such ligands for receptor localization studies.

L'invention concerne des analogues de la 2-phénoxypyrimidinone, de formule : dans laquelle les variables sont telles que décrites ici. De tels composés sont des ligands qui peuvent être utilisés pour moduler l'activité de récepteurs particuliers in vivo ou in vitro et qui sont particulièrement utiles dans le traitement d'affections associées à l'activation pathologique de récepteurs chez des humains, des animaux de compagnie domestiqués et le bétail. L'invention concerne également des compositions pharmaceutiques et des procédés d'utilisation de tels composés pour traiter de tels troubles, ainsi que des procédés d'utilisation de tels ligands pour des études de localisation de récepteurs.

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