2-phenyl-4-cyclopropyl-pyrimidine derivatives

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/12 (2006.01) A61K 31/506 (2006.01) A61P 7/02 (2006.01)

Patent

CA 2719569

The present invention relates to 2-phenyl-4-cyclopropyl-pyrimidine derivatives and their use as P2Y12 receptor an-tagonists in the treatment and/or prevention of peripheral vascular, of visceral-, hepatic- and renal-vascular, of cardiovascular and of cerebrovascular diseases or conditions associated with platelet aggregation, including thrombosis in humans and other mam-mals.

La présente invention concerne des dérivés de 2-phényl-4-cyclopropyl-pyrimidine et leur utilisation comme antagonistes du récepteur P2Y12 dans le traitement et/ou la prévention des maladies vasculaires périphériques, viscéro-vasculaires, hépato-vasculaires et réno-vasculaires, cardiovasculaires et cérébrovasculaires ou des états associés à lagrégation plaquettaire, y compris la thrombose chez les humains et les autres mammifères.

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