2-phenyl-benzimidazol and 2-phenyl-imidazo-`4,5!-pyridine...

Details 2-phenyl-benzimidazol and 2-phenyl-imidazo-`4,5!-pyridine... 2-phenyl-benzimidazol and 2-phenyl-imidazo-`4,5!-pyridine...

C - Chemistry, Metallurgy

07

D

C07D 235/18 (2006.01) A61K 31/395 (2006.01) A61K 31/4184 (2006.01) C07D 401/10 (2006.01) C07D 401/12 (2006.01) C07D 403/12 (2006.01) C07D 405/10 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01)

Patent

CA 2522562

2-Phenyl substituted benzimidazoles and imidazo[4,51pyridines of formula (I)are disclosed as inhibitors of Cds1 and useful as adjuvants to chemotherapy or radiation therapy in the treatment of cancer. Wherein W is -COOH, -(CO)NH2, or -(SO2)NH2; Q is N or CH; Z is selected from the group consisting of a) >C=O, >C=CHRf, >CRdRd, >CF2, >CRdORe, >C(ORd)ORe, b) >C(Rd)NRdRg, C) - SO2NRdC(Rh)2-, where A is fuse d at the b or c faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, where A is fused at the b or c; faces, at a face of A which contains two carbon atoms, which is saturated or unsaturated, d) >NC1-4alkyl, where the alkyl is optionally substituted with a. substituent selected from the group consisting of -NH2, - NHC1-4alkyl, -N(C1-4aIkyl)2, -CONH2, -CONHC1-4alkyl-, -CON(C1-4aIkyl)2, -COOH, --COOC1-4alkyl, -OH and -OC1-4alkyl; A is selected from the group consisting of: a) phenyl or other substituents defined in claim1. The other substituents are as defined in claim1.

L'invention concerne benzimidazoles à substitution phényle en 2 et des imidazo[4,5] pyridines, représentés par la formule (I), utilisés comme inhibiteurs de Cds1, et convenant comme adjuvants à la chimiothérapie et à la radiothérapie dans les traitements anticancéreux.(I) W représente -COOH, -(CO)NH¿2?, ou -(SO¿2?)NH¿2?; Q représente N ou CH; Z est choisi dans le groupe constitué par a) >C=O, >C=CHR¿f?, >CR¿d?R¿d?, >CF¿2?, >CR¿d?OR¿e?, >C(OR¿d?)OR¿e?, b) >C(R¿d?)NR¿d?R¿g?, C) -SO¿2?NR¿d?C(R¿h?)¿2-?,(II) A étant accolé aux faces b ou c, par une face de A qui contient deux atomes de carbone, et qui est saturée ou insaturée, (III) A étant accolé aux faces b ou c, sur une face de A contenant deux atomes de carbone, et qui est saturée ou insaturée, d) >N-alkyle C¿1-4?, l'alkyle comprenant éventuellement une substitution par un substituant choisi dans le groupe constitué par -NH¿2?, -NH-alkyle C¿1-4?, -N(aIkyle C¿1-4?)¿2?, -CONH¿2?, - CONH-alkyl C¿1-4 ?-, -CON(aIkyle C¿1-4?)¿2?, -COOH, -COO-alkyle C¿1-4?, -OH et O-alkyle C¿1-4?; A est choisi dans le groupe constitué par a) phényl ou d'autres substituants définis dans la revendication 1. Les autres substituants sont tels que définis dans la revendication 1.

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