2-phenyl-indoles as prostaglandin d2 receptor antagonists

Details 2-phenyl-indoles as prostaglandin d2 receptor antagonists 2-phenyl-indoles as prostaglandin d2 receptor antagonists

C - Chemistry, Metallurgy

07

D

C07D 209/18 (2006.01) A61K 31/404 (2006.01) A61P 11/06 (2006.01) A61P 27/14 (2006.01) A61P 37/06 (2006.01) A61P 37/08 (2006.01)

Patent

CA 2659055

The present invention is directed to 2-phenyl-indole compounds (A), their preparation, pharmaceutical compositions containing these compounds, and their pharmaceutical use in treating a patient suffering from a PGD2-mediated disorder including, but not limited to, allergic disease (such as allergic rhinitis, allergic conjunctivitis, atopic dermatitis, bronchial asthma and food allergy), systemic mastocytosis, disorders accompanied by systemic mast cell activation, anaphylaxis shock, bronchoconstriction, bronchitis, eczema, urticaria diseases accompanied by itch (such as atopic dermatitis and urticaria), diseases (such as cataract, retinal detachment, inflammation, infection and sleeping disorders) which are generated secondarily as a result of behavior accompanied by itch (such as scratching and beating), inflammation, chronic obstructive pulmonary diseases, ischemic reperfusion injury, cerebrovascular accident, chronic rheumatoid arthritis, pleurisy, ulcerative colitis and the like.

La présente invention concerne des composés de 2-phényl-indole (A), leur préparation, des compositions pharmaceutiques contenant ces composés et leur utilisation pharmaceutique pour traiter un patient qui présente un trouble induit par la PGD2 y compris, mais non limitativement, une maladie allergique (telle que la rhinite allergique, la conjonctivite allergique, la dermatite atopique, l'asthme bronchique et l'allergie alimentaire), la mastocytose systémique, les troubles accompagnés de l'activation des mastocytes systémiques, le choc anaphylactique, la bronchoconstriction, la bronchite, l'eczéma, les maladies de type urticaire accompagnées de démangeaisons (tels que la dermatite atopique et l'urticaire), des maladies (telles que la cataracte, le détachement rétinien, l'inflammation, l'infection et les troubles du sommeil) qui sont le résultat d'un comportement lié aux démangeaisons (tel que le fait de se gratter ou de se taper), l'inflammation, la bronchopneumopathie chronique obstructive, les lésions d'ischémie-reperfusion, un accident vasculaire cérébral, la polyarthrite chronique rhumatismale, la pleurésie, la rectocolite hémorragique et des maladies similaires.

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