2-(phenyl or heterocyclic)-1h-phenanthro[9,10-d]imidazoles

Details 2-(phenyl or heterocyclic)-1h-phenanthro[9,10-d]imidazoles 2-(phenyl or heterocyclic)-1h-phenanthro[9,10-d]imidazoles

C - Chemistry, Metallurgy

07

D

C07D 235/02 (2006.01) A61K 31/4184 (2006.01)

Patent

CA 2643562

The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

La présente invention concerne les nouveaux composés de Formule (I) ou les sels de qualité pharmaceutique desdits composés. Lesdits composés sont des inhibiteurs de l'enzyme prostaglandine E synthétase microsomale 1 (mPGES-1) et peuvent donc être employés dans le traitement de douleurs et/ou d'inflammations dues à un grand nombre de maladies ou d'états pathologiques, tels que l'ostéoarthrose, la polyarthrite rhumatoïde et les douleurs aiguës ou chroniques. La présente invention concerne également des méthodes de traitement des maladies ou des états pathologiques dans lesquels intervient l'enzyme mPGES-1, ainsi que des compositions pharmaceutiques.

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