C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/02 (2006.01) A61K 31/4184 (2006.01) C07D 401/04 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2629527
The invention encompasses novel compounds of Formula (I) or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.
L'invention porte sur de nouveaux composés de la formule (I) ou sur des sels pharmaceutiquement acceptables de ces derniers. Les composés de l'invention sont des inhibiteurs de l'enzyme prostaglandine E synthase-1 microsomale (mPGES-1) et sont par conséquent utilisés pour traiter la douleur et/ou l'inflammation provoquées par une variété d'états et de pathologies, tels que l'ostéoarthrite, l'arthrite rhumatoïde et la douleur aiguë ou chronique. L'invention se rapporte également à des procédés permettant de traiter des états ou pathologies médiés par l'enzyme mPGES-1 et à des compositions pharmaceutiques.
Chau Anh
Cote Bernard
Ducharme Yves
Frenette Richard
Friesen Richard
Merck Frosst Canada Ltd.
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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