2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles...

Details 2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles... 2-(phenyl or heterocyclic)-1h-phenantrho[9,10-d]imidazoles...

C - Chemistry, Metallurgy

07

D

C07D 235/02 (2006.01) A61K 31/4164 (2006.01) A61K 31/4439 (2006.01) C07D 401/04 (2006.01) C07D 403/04 (2006.01)

Patent

CA 2591724

The invention encompasses novel compounds of Formula I INSERT FORMULA I FROM CLAIM 1 or pharmaceutically acceptable salts thereof. These compounds are inhibitors of the microsomal prostaglandin E synthase-1 (mPGES-1) enzyme and are therefore useful to treat pain and/or inflammation from a variety of diseases or conditions, such as osteoarthritis, rheumatoid arthritis and acute or chronic pain. Methods of treating diseases or conditions mediated by the mPGES-1 enzyme and pharmaceutical compositions are also encompassed.

La présente invention concerne de nouveaux composés de Formule I INSÉRER LA FORMULE I DE LA REVENDICATION 1 ou des sels de qualité pharmaceutique de ces composés. Lesdits composés sont des inhibiteurs de l'enzyme prostaglandine E synthétase microsomale 1 (mPGES-1) et peuvent donc être employés pour le traitement de douleurs et/ou d'inflammations dues à un grand nombre de maladies ou d'états pathologiques, tels que l'ostéoarthrose, la polyarthrite rhumatoïde et les douleurs aiguës ou chroniques. La présente invention décrit également des méthodes de traitement des maladies ou des états pathologiques dans lesquelles intervient l'enzyme mPGES-1, ainsi que des préparations pharmaceutiques.

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