2-phenyl substituted imidazotriazinones as phosphodiesterase...

Details 2-phenyl substituted imidazotriazinones as phosphodiesterase... 2-phenyl substituted imidazotriazinones as phosphodiesterase...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/53 (2006.01) C07F 9/6561 (2006.01)

Patent

CA 2309332

The 2-phenyl-substituted imidazotriazinones having short, unbranched alkyl radicals in the 9-position are prepared from the corresponding 2-phenyl-imidazotriazinones by chlorosulphonation and subsequent reaction with the amines. The compounds inhibit cGMP-metabolizing phosphodiesterases and are suitable for use as active compounds in pharmaceuticals, for the treatment of cardiovascular and cerebrovascular disorders and/or disorders of the urogenital system, in particular for the treatment of erectile dysfunction.

Ces imidazotriazinones à substitution 2-phényle, présentant des radicaux alkyle courts non ramifiés dans la position 9 selon la formule générale (I), sont produits à partir des 2-phényl-imidazotriazinones correspondantes par chlorosulfonation et réaction subséquente avec les amines. Ces composés inhibent les phosphodiestérases métabolisant le GMP cyclique et conviennent comme principes actifs dans des médicaments, pour le traitement des maladies cardiovasculaires et cérébrovasculaires et/ou des maladies du système uro-génital, notamment pour le traitement de la dysérection.

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