C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/18 (2006.01) A61K 31/10 (2006.01) A61K 31/404 (2006.01) A61K 31/41 (2006.01) A61K 31/4184 (2006.01) A61K 31/454 (2006.01) A61P 3/10 (2006.01) A61P 7/02 (2006.01) A61P 9/00 (2006.01) A61P 13/12 (2006.01) A61P 25/00 (2006.01) A61P 25/08 (2006.01) A61P 25/14 (2006.01) A61P 25/16 (2006.01) A61P 25/28 (2006.01) A61P 29/00 (2006.01) A61P 31/00 (2006.01) A61P 35/00 (2006.01) A61P 35/04 (2006.01) A61P 37/02 (2006.01) A61P 43/00 (2006.01) C07D 209/14 (2006.01) C07D 235/04 (2006.01)
Patent
CA 2350734
The invention relates to the use of 2-phenyl-benzimidazoles and 2- phenylindoles of general formula (I), wherein A means N or CH, R1 means hydrogen, branched and unbranched C1-C6 alkyl and a C-atom of the alkyl radical can also carry an OR11 or a group R5, R2 means hydrogen, chlorine, fluorine, bromine, iodine, branched and unbranched C1-C6 alkyl, nitro, CF3, CN, NR21R22, NH-CO-R23, OR21, R3 means(CH2)q-NR31R32 and q can be 0, 1, 2 or 3 and R4 means hydrogen, branched and unbranched C1-C6 alkyl, chlorine, bromine, fluorine, nitro, cyano, NR41R42, NH-CO-R43, OR41; as inhibitors of the enzyme poly(ADP-ribose)-polymerase for producing medicaments.
L'invention concerne l'utilisation de 2-phényl-benzimidazoles et de 2-phénylindoles de la formule générale (I), où A représente N ou CH, R<1> représente hydrogène, alkyle C1-C6 ramifié et non ramifié, un atome de carbone du reste alkyle pouvant encore porter OR<11> ou un groupe R<5>, R<2> représente hydrogène, chlore, fluor, brome, iode, alkyle C1-C6 ramifié et non ramifié, nitro, CF3, CN, NR<21>R<22>, NH-CO-R<23>, OR<21>, R<3> représente(CH2)q-NR<31>R<32>, q pouvant valoir 0, 1, 2 ou 3, R<4> représente hydrogène, alkyle C1-C6 ramifié et non ramifié, chlore, brome fluor, nitro, cyano, NR<41>R<42>, NH-CO-R<43>, OR<41?, comme inhibiteurs de l'enzyme Poly(ADP-ribose)-polymérase pour la production de médicaments.
Hoger Thomas
Kock Michael
Lubisch Wilfried
Abbott Gmbh & Co. Kg
Basf Aktiengesellschaft
Robic
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