C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 307/79 (2006.01) A61K 31/34 (2006.01) A61K 31/38 (2006.01) A61K 31/445 (2006.01) A61K 31/535 (2006.01) C07D 307/80 (2006.01) C07D 307/81 (2006.01) C07D 333/54 (2006.01) C07D 333/56 (2006.01) C07D 333/58 (2006.01) C07D 405/06 (2006.01) C07D 409/06 (2006.01) C07D 413/06 (2006.01)
Patent
CA 2110062
Abstract The invention relates to new furans and thiophenes with the general Formula I, Image (I) in which R1 and R2 independently of one another denote a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a benzyl group, a group C(O)R4, wherein R4 is an alkyl or alkoxy group having 1 to 10 carbon atoms or a phenyl radical, or a carbamoyl group -C(O)NR5R6, where R5 and R6 independently of one another are a hydrogen atom or an alkyl group having 1 to 10 carbon atoms, and n denotes an integer from 0 to 12 if R3 is a hydrogen atom, or n denotes an integer from 4 to 12 if R3 is an amino group -NR7R8, where R7 and R8 independently of one another represent a hydrogen atom or an alkyl group having 1 to 10 carbon atoms or R7 and R8 together represent an alkylene group -(CH2)N- or the group -(CH2)2O(CH2)2- or R3 denotes an amide group -C(O)NR7R8, wherein R7 and R8 have the abovementioned meanings, or R3 denotes a sulphinyl group -S(O)R9, where R9 is the radical -(CH2)m(CF2)oCF3 and m and o are 2, 3, 4, 5 or 6 and x denotes an oxygen or sulphur atom. These new compounds are strong and selective anti-oestrogens, and have therapeutic applications in the treatment of oestrogen-related illnesses.
Erber Sebastian
Schneider Martin
von Angerer Erwin
Marks & Clerk
Schering Aktiengesellschaft
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