C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
167/207, 260/246
C07D 337/08 (2006.01) C07D 313/08 (2006.01) C07D 405/02 (2006.01) C07D 405/12 (2006.01) C07D 413/04 (2006.01)
Patent
CA 1277320
ABSTRACT OF THE DISCLOSURE The invention is concerned with novel 2-phenyl- benzoxepin derivatives having the general formula (I): (I) Image Wherein R1 and R2 idenpendently represent a hydrogen atom, halogen atom, hydroxyl group, methyl group or methoxy group; R3 and R4 independently represent a hydrogen atom, lower alkyl group of the group -(CH2)n-Y wherein n represents an integer of 1 to 5, and Y represents an optionally substituted aromatic group or heterocyclic group; or R3 and R4, together with a nitrogen atom to which they are bonded, form an optionally substituted heterocyclic group; and R5 re- presents a hydrogen atom, halogen atom, optionally substituted alkyl group, hydroxymethyl group, or optionally esterized or amidated carboxyl group, and pharmaceutically acceptable acid addition salts there- of. The 2-phenylbenzoxepin derivatives of formula (I) have a hypoglycemic activity, hypotensive activity, and platelet coagulation inhibiting activity.
540116
Ishihara Takafumi
Miyano Seiji
Nomura Kayoko
Satoh Fumio
Sumoto Kunihiro
Suntory Limited
Swabey Ogilvy Renault
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