C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 235/24 (2006.01) A61K 31/4184 (2006.01) A61P 9/10 (2006.01)
Patent
CA 2399799
The subject invention relates to compounds having the structure: (I), wherein: (a) R1 is selected from alkyl, aryl, alkoxy, and aryloxy; (b) R3 and R4 are independently selected from hydrogen, halo, alkyl, alkoxy, alkylthio, and alkylamino, but R3 and R4 are not both hydrogen; (c) each R5 is independently selected from hydrogen, halo, cyano, alkyl, hydroxy, alkoxy, thio, alkylthio, amino, and alkylamino; (d) each R6 is independently selected from hydrogen, halo, nitro, cyano, alkyl, aryl, heterocyclyl, hydroxy, alkoxy, aryloxy, thio, alkylthio, arylthio, amino, alkylamino, arylamino, acyl, alkylacyl, arylacyl, amido, alkylamido, arylamido, sulfonyl, alkylsulfonyl, arylsulfonyl, phosphonyl, alkylphosphonyl, arylphosphonyl, carboxy and its alkyl and aryl esters.The subject compounds are useful for preventing or treating reperfusion injury of a variety of tissues.
La présente invention concerne des composés présentant la structure (I), dans laquelle (a) R1 est choisi parmi alkyle, aryle, alcoxy et aryloxy, (b) R3 et R4 sont indépendamment choisis parmi hydrogène, halo, alkyle, alcoxy, alkylthio et alkylamino, mais R3 et R4 ne sont pas tous deux hydrogène, (c) chaque R5 est indépendamment choisi parmi hydrogène, halo, cyano, alkyle, hydroxy, alcoxy, thio, alkylthio, amino et alkylamino, (d) chaque R6 est indépendamment choisi parmi hydrogène, halo, nitro, cyano, alkyle, aryle, hétérocyclyle, hydroxy, alcoxy, aryloxy, thio, alkylthio, arylthio, amino, alkylamino, arylamino, acyle, alkyacyle, arylacyle, amido, alkylamido, arylamido, sulfonyle, alkylsulfonyle, arylsulfonyle, phosphonyle, alkylphosphonyle, arylphosphonyle, carboxy et ses esters d'alkyle et d'aryle. Les composés de l'invention sont utiles pour prévenir ou traiter une lésion consécutive à une perfusion sur une pluralité de tissus.
Chianelli Donatella
Nikolaides Nicholas
Ledgley Law
The Procter & Gamble Company
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