C - Chemistry – Metallurgy – 07 – C
Patent
C - Chemistry, Metallurgy
07
C
C07C 309/65 (2006.01) A61K 31/255 (2006.01) A61P 11/00 (2006.01) C07D 277/46 (2006.01) C07D 295/12 (2006.01)
Patent
CA 2553705
(R)-2-[4-(Trifluoromethanesulphonyloxy)phenyl]propionamide derivatives of_ formula (I), where the variables are as defined in the claims, and pharmaceutical compositions containing such compounds are useful in inhibiting. the chemotactic activation of neutrophils (PMN leukocytes) induced by the interaction of interieukin-8 (IL-8) with CXCRI and CXCR2 membrane receptors. The compounds are used for the prevention and treatment of pathologies deriving from said activation. Notably, these metabolites are devoid of cyclooxygenase inhibition. activity and are particularly useful in the treatment of neutrophil-dependent pathologies such as psoriasis, ulcerative colitis, melanoma, chronic obstructive pulmonary disease (COPD), bullous pemphigoid, rheumatoid arthritis, idiopathic fibrosis, glomerulonephritis and in the prevention and treatment of damages caused by ischemia and reperfusion.
Selon la présente invention, des dérivés de l'acide 4-(trifluorométhanesulfonyloxyphényl)propionique et une composition pharmaceutique contenant ces composés sont utiles pour inhiber l'activation chimiotactique des neutrophiles (leucocytes PMN) induite par l'interaction de l'interleukine 8 (IL-8) avec les récepteurs membranaires CXCR1 et CXCR2. Ces composés sont utilisés dans la prévention et le traitement de pathologies dérivées de cette activation. Notablement, ces métabolites sont dépourvus d'activité d'inhibition de la cyclo-oxygénase et sont particulièrement utiles dans le traitement de pathologies neutrophiles-dépendantes, telles que le psoriasis, la colite ulcéreuse, le mélanome, la bronchopneumopathie chronique obstructive (BPCO), la pemphigoïde bulleuse, la polyarthrite rhumatoïde, la fibrose idiopathique, la glomérulonéphrite ainsi que dans la prévention et le traitement de lésions d'ischémie et de reperfusion.
Allegretti Marcello
Bertini Riccardo
Cesta Maria Candida
Colotta Francesco
Mosca Marco
Dompe Pha.r.ma S.p.a
Dompe S.p.a.
Kirby Eades Gale Baker
LandOfFree
2-phenylpropionic acid derivatives and pharmaceutical... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 2-phenylpropionic acid derivatives and pharmaceutical..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 2-phenylpropionic acid derivatives and pharmaceutical... will most certainly appreciate the feedback.
Profile ID: LFCA-PAI-O-1856614