2-picolylamine derivatives

Details 2-picolylamine derivatives 2-picolylamine derivatives

C - Chemistry, Metallurgy

07

D

167/228, 260/290

C07D 213/56 (2006.01) A61K 31/44 (2006.01) C07D 213/40 (2006.01)

Patent

CA 2011277

ABSTRACT 57 The present invention relates to novel 2-picolylamine derivatives of general formula 1 Image (I) wherein R1 represents an alkyl or phenylalkyl radical; R2 is hydrogen, C1-C4 acyl or C1-C4 alkoxycarbonyl; R3 is either an electron pair, in which case t means nothing and q is 0, or R3 is hydrogen or C1-C4, in which case t is (+) and q=1; Z is oxygen or an aminocarboniloxy group;X is O or S; m and n are 2-6; p is 0-3; A- is a pharmaceutically acceptable ion. These compounds are PAF antagonists and, consequently, useful in the treatment of the diseases in which this substance is involved.

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