2-piperazinone compounds, their production and use

Details 2-piperazinone compounds, their production and use 2-piperazinone compounds, their production and use

C - Chemistry, Metallurgy

07

D

C07D 241/08 (2006.01) A61K 31/495 (2006.01) A61K 31/535 (2006.01) C07D 401/12 (2006.01) C07D 403/02 (2006.01) C07D 403/06 (2006.01) C07D 405/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01) C07D 417/12 (2006.01) C07K 5/083 (2006.01) C07K 5/087 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2076619

Abstract The compounds of the formula Image ; wherein G stands for an amidino group or an optionally cyclic amino group, these being respectively optionally substituted; D stands for a spacer having 2 to 6 atomic chain optionally bonded through a hetero-atom and/or a 5- to 6-membered ring (provided that the 5- to 6- membered ring is, depending on its bonding position, counted as 2 to 3 atomic chains); R1 stands for hydrogen, benzyl group or a lower alkyl group; R2 and R3 independently stand for a residual group formed by removing -CH(NH2)COOH from an .alpha.-amino acid, or R1 and R2 may form a 5- to 6-membered ring taken together with the adjacent N and C; X stands for hydrogen or an optionally substituted lower alkyl group; and Z stands for a group capable of forming an anion or a group convertible into an anion in a living body, or salts thereof and agents for inhibiting cell-adhesion, which are characterized by containing these compounds. The novel compounds and pharmaceutical agents are effective for prophylaxis and therapy of various diseases by controlling or inhibiting cell adhesion.

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