2-piperazinyl-6,7-dimethoxyquinazolines

C - Chemistry – Metallurgy – 07 – D

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C07D 403/04 (2006.01) A61K 31/495 (2006.01) A61K 31/505 (2006.01) C07D 239/00 (2006.01) C07D 239/72 (2006.01) C07D 239/94 (2006.01) C07D 239/95 (2006.01) C07D 241/00 (2006.01) C07D 241/04 (2006.01) C07D 295/00 (2006.01) C07D 295/18 (2006.01)

Patent

CA 1090803

2-PIPERAZINYL-6,7-DIMETHOXYQUINAZOLINES Abstract of the Disclosure A series of novel 4-amino or 4-hydrazino-2-(substituted piperazinyl)-6,7-dimethoxyquinazolines is disclosed having anti- hypertensive and phosphodiesterase inhibiting properties. Piperazinyl substituents include cycloalkenylcarbonyl, cycloalkylcarbonyl, and methylcycloalkylcarbonyl. A representative embodiment of the invention is 4-amino-2-[4-(cyclopentylcarbonyl)-1-piperazinyl]-6,7- dimethoxyquinazoline.

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