2-piperidino-1-alkanol derivatives as antiischemic agents

C - Chemistry – Metallurgy – 07 – D

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C07D 451/04 (2006.01) A61K 31/395 (2006.01) C07D 207/12 (2006.01) C07D 211/44 (2006.01) C07D 211/48 (2006.01) C07D 211/52 (2006.01) C07D 211/54 (2006.01) C07D 211/70 (2006.01) C07D 409/00 (2006.01) C07D 451/02 (2006.01) C07D 451/06 (2006.01) C07D 491/00 (2006.01) C07D 491/20 (2006.01)

Patent

CA 2016860

2-(8-Azabicyclo[3.2.1]oct-8-yl)alkanols of the formula Image wherein Q is S or CH=CH; X is H, OH or another aromatic substituent; R is hydrogen, alkyl, alkenyl or alkynyl; Y and y1 are taken together and are arylmethylene or aralkylmethylene (or a corresponding epoxy derivative) or Y and y1 are taken separately and Y is hydrogen or OH, and y1 is aryl, aralkyl, arylthio, or aryloxy; and structurally related 2-(piperidino)alkanols; pharmaceutical compositions thereof; methods of treating CNS disorders therewith; and intermediates useful in the preparation of said compounds.

2-(8-Azabicyclo¢3.2.1!oct-8-yl)alcanols de formule Image , où Q est S ou CH=CH; X est H, OH ou un autre substituant aromatique; R est de l'hydrogène, un groupe alkyle, alcényle ou alcynyle; Y et y1 pris ensemble représentent un arylméthylène ou un aralkylméthylène (ou un dérivé époxy correspondant), ou, si Y et y1 sont séparés, Y est de l'hydrogène ou OH, et y1 est un groupe aryle, aralkyle, arylthio ou aryloxy; 2-(pipéridino)alcanols structurellement apparentés; leurs compositions pharmaceutiques; méthodes pour traiter les troubles du SNC grâce à ces composés; intermédiaires utiles pour les préparer.

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