2-propanol and 2-propylamine derivatives and their use as...

Details 2-propanol and 2-propylamine derivatives and their use as... 2-propanol and 2-propylamine derivatives and their use as...

C - Chemistry, Metallurgy

07

D

C07D 405/06 (2006.01) A61K 31/352 (2006.01) A61K 31/404 (2006.01) A61K 31/47 (2006.01) A61P 29/00 (2006.01) A61P 37/02 (2006.01) C07D 215/14 (2006.01) C07D 311/58 (2006.01) C07D 471/04 (2006.01)

Patent

CA 2558023

Compounds of Formula (IA) and Formula (IB): wherein in R1 stands for the following group (the dashed line indicates the point of attachement) and R2, R3, R4, R5, R6, Y, Z, X1 and X2 are as defined herein for Formula (IA) and Formula (IB), or a tautomer, prodrug, solvate, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

L'invention concerne des composés de formule (IA) et de formule (IB) : dans lesquelles R?1¿ représente le groupe suivant (la ligne en pointillés indique le point de fixation) : et R?2¿, R?3¿, R?4¿, R?5¿, R?6¿, Y, Z, X?1¿ et X?2¿ sont tels que définis dans la description pour la formule (IA) et la formule (IB), ou un tautomère, un promédicament, un solvate ou un sel de celui-ci. L'invention concerne également des compositions pharmaceutiques contenant lesdits composés, ainsi que des méthodes de modulation de la fonction des récepteurs glucocorticoïdes et des méthodes de traitement des maladies, des affections ou des états induits par la fonction des récepteurs glucocorticoïdes ou caractérisés par des processus inflammatoires, allergiques ou prolifératifs chez un patient, au moyen des composés selon l'invention.

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