2-pyrazolin-5-ones

C - Chemistry – Metallurgy – 07 – D

Patent

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Details

C07D 403/06 (2006.01) A61K 31/4152 (2006.01) A61P 35/00 (2006.01) C07D 231/20 (2006.01) C07D 401/06 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 405/14 (2006.01) C07D 409/14 (2006.01) C07D 413/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2380644

Chemical compounds having structural formula (I) and physiologically acceptable salts thereof, are inhibitors of serine/threonine and tyrosine kinase activity. Several of the tyrosine kinases, whose activity is inhibited by these chemical compounds, are involved in angiogenic processes. Thus, these chemical compounds can ameliorate disease states where angiogenesis or endothelial cell hyperproliferation is a factor. These compounds can be used to treat cancer and hyperproliferative disorders.

Cette invention se rapporte à des composés chimiques représentés par la formule développée (I), et à des sels physiologiquement acceptables de ces composés, qui sont des agents inhibiteurs de l'activité des sérine/thréonine kinases et des tyrosine kinases. Plusieurs des tyrosine kinases dont l'activité est inhibée par ces composés chimiques sont impliquées dans des processus d'angiogenèse. Par conséquent, ces composés chimiques peuvent améliorer les états pathologiques dans lesquels l'angiogenèse ou l'hyperprolifération de cellules endothéliales constituent un facteur. Ces composés peuvent servir à traiter le cancer et les troubles hyperprolifératifs.

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