2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

Details 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-ones

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61P 35/00 (2006.01)

Patent

CA 2555724

This invention provides compounds of formula I:R1 wherein R', R2, R3, R4, and X1 are as defined in the specification. The 2-(pyridin-3-ylamino)-pyrido[2,3- d]pyrimidin-7-one compounds of formula I, which are inhibitors of cyclin- dependent kinases 2 and 4 (Cdk2 and Cdk4), are useful in treating cell proliferative disorders.

L'invention concerne des composés représentés par la formule (I), dans laquelle R', R?2¿, R?3¿, R?4¿, et X?1¿ sont tels que définis dans le descriptif. Les composés 2-(pyridin-3-ylamino)-pyrido[2,3-d]pyrimidin-7-one de la formule I, qui sont des inhibiteurs des kinases dépendantes des cyclines 2 et 4 (Cdk2 et Cdk4), sont utilisés dans le traitement des troubles de la prolifération cellulaire.

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