2-pyridine derivatives as inhibitors of neutrophile elastase

Details 2-pyridine derivatives as inhibitors of neutrophile elastase 2-pyridine derivatives as inhibitors of neutrophile elastase

C - Chemistry, Metallurgy

07

D

C07D 213/82 (2006.01) A61K 31/4412 (2006.01) A61K 31/4427 (2006.01) A61K 31/444 (2006.01) A61P 11/00 (2006.01) A61P 11/06 (2006.01) A61P 29/00 (2006.01) C07D 213/83 (2006.01) C07D 401/12 (2006.01) C07D 409/12 (2006.01) C07D 413/12 (2006.01)

Patent

CA 2600038

The invention provides compounds of formula wherein R1, R3, R4, R5, R6, R14, X, W and Z are as defined in the specification and optical isomers, racemates and tautomers thereof, and pharmaceutically acceptable salts thereof; together with processes for their preparation, pharmaceutical compositions containing them and their use in therapy. The compounds are inhibitors of human neutrophil elastase.

L'invention concerne de des composés de formule (I) dans laquelle R<SUP>1</SUP>, R<SUP>3</SUP>, R<SUP>4</SUP>, R<SUP>5</SUP>, R<SUP>6</SUP>, R<SUP>14</SUP>, X, W et Z sont tels que définis dans le mémorandum descriptif, des isomères optiques, des racémates, des tautomères et des sels pharmaceutiquement acceptables desdits composés. Elle concerne également des méthodes de préparation des composés, des compositions pharmaceutiques contenant les composés, et l'utilisation des composés en thérapie. Les composés de l'invention sont des inhibiteurs de la neutrophile élastase.

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