2-pyridinol derivatives and their use as medicaments

Details 2-pyridinol derivatives and their use as medicaments 2-pyridinol derivatives and their use as medicaments

C - Chemistry, Metallurgy

07

F

C07F 9/59 (2006.01) A61K 31/44 (2006.01) A61K 31/675 (2006.01) C07D 213/64 (2006.01) C07D 401/04 (2006.01) C07D 405/04 (2006.01) C07D 491/04 (2006.01) C07F 9/58 (2006.01)

Patent

CA 2124001

2124001 9310093 PCTABS00022 Compounds of formula (1) or a pharmaceutically acceptable salt thereof, wherein: R0 is OH or a bioprecursor thereof, R1 is A0CO2H, P(Z)(OH)(OR2), SO2H or SO3H or a bioprecursor thereof, A0 is CH2, CHF, CF2, CR3(OR4), CO or C(OR5)(OR6), are described as agonists of a cyclic AMP-dependent protein kinase. They are useful as medicaments.

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