C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
260/277.1, 260/2
C07D 409/12 (2006.01)
Patent
CA 1297109
Abstract The invention relates to a process for the preparation of new nitrogen-arylmethoxy-thiophen derivatives of the general formula I on the sheet of forrnulae, in which the R-CH20-group is in position 4 or 5 of the thiophene ring, R denotes a 2-pyridinyl or 2-quinolinyl group and Rl denotes a -C00-lower alkyl,-C0-(CH2)n-CH3 or -CH(OH)-(CH2)n-CH3 group, wherein n represents an integer from 2 to 6, and their hydrates and/or their pharmaceutically acceptable acid addition salts, by reacting 4- or 5-Hydroxy-thiophen derivatives of formula ll with substituted alkylhalogenides of the formula III and, if appropriate, reducing the keto-group of the resulting compounds of the formula I to the alcohol, or byreacting aldehydes of formula IV on the sheet of formula with lithiumalkyls or Grignard-agents of the formula V and, if appropriate, oxidizing the alcohol group of the resulting co,npounds to the keto-group of formula I and, if desired, converting the resulting compounds of the formula I into pharmaceutically usablesalts. The new compounds and their salts can be used as active compounds for medicaments for the treatment and prevention of diseases, caused by a distur- bance in arachidonic acid metabolism. O.Z.812 17 12 1986
526227
Binder Dieter
Ferber Hubert Peter
Rovenszky Franz
Schror Karsten
Chemisch Pharma - Zeutische Forschungsgesellschaft M.b.h.
Riches Mckenzie & Herbert Llp
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