2-(pyridinyl or hydroxyphenyl)pyrido-(2,3-d)...

Details 2-(pyridinyl or hydroxyphenyl)pyrido-(2,3-d)... 2-(pyridinyl or hydroxyphenyl)pyrido-(2,3-d)...

C - Chemistry, Metallurgy

07

D

260/242.5

C07D 471/04 (2006.01) C07D 239/42 (2006.01) C07D 319/06 (2006.01) C07D 407/12 (2006.01) C07D 407/14 (2006.01)

Patent

CA 1234111

ABSTRACT OF THE DISCLOSURE 2-Q-6-Q'-8-R-pyrido[2,3-d]pyrimidin-5(8H)-ones of the formula (I), Image where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-methoxyphenyl, 4(or 3)- pyridinyl or 4(or 3)-pyridinyl having one or two lower-alkyl sub- stituents, R' is hydrogen or alkyl having one to four carbon atoms, Q is hydrogen, amino or nitro, and R is alkyl having from one to four carbon atoms, CH(C2H5)2, (CH2)nCH=CH2 where n is 1 or 2, or Y-Z where Y is alkylene having from two to four carbon atoms and having its connecting linkages on different carbon atoms and Z is hydroxy, OR1 or NR1R2 where R1 and R2 are each methyl or ethyl, or acid-addition salts thereof, and their pre- paration are shown. Also shown is the cardiotonic use of I where Q is 4(or 3)-hydroxyphenyl, 4(or 3)-pyridinyl or 4(or 3)- pyridinyl having one or two lower-alkyl substituents and Q' is hydrogen or amino.

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